Glycomics and genetics and scrapie

Originally from: paul barton
                        
My work is primarily with people and based upon what we are seeing with genetic conditions like cystic fibrosis, muscular dystrophy, downs syndrome I'm wondering if there is a chance that we can impact scrapie resistance? It would need a well structured trial but the work we've seen with people suggests that its worth a look. What do you think. paul barton

Originally from: Bill
                        
When you say "genetic conditions like cystic fibrosis", Paul, I assume you are aware that congenital CF can be induced by selenium deficiency, as was discovered way back in 1978 at the Yerkes Regional Primate Research Center, Emory University, Atlanta, GA.

Selenium deficiency is implicated in Muscular Dysrophy, also Lipodystrophy, and as selenium is intrinsically involved in gene replication and cell division it is perhaps unsurprising that the aforementioned conditions often have associated congenital genetic aberrations.

All the best,
Bill.
                        

Originally from: paul barton
                        
Hi Bill – thanks for that insight. Using Glyconutrients and a calcium channel blocking drug we've seen at least on MD case reverse totally. The paper is on www.glycoscience.org . I am wondering if we can impact Scrapie and the Valine thread by using a similar strategy.
Regards paul

From: ...

Originally from: ... [...] Sent: 04 October 2004 21:00
To: ...
Subject: Re: [farmtalking] Glycomics and genetics and scrapie

When you say "genetic conditions like cystic fibrosis", Paul, I assume you are aware that congenital CF can be induced by selenium deficiency, as was discovered way back in 1978 at the Yerkes Regional Primate Research Center, Emory
University, Atlanta, GA.

Selenium deficiency is implicated in Muscular Dysrophy, also Lipodystrophy, and as selenium is intrinsically involved in gene replication and cell division
it is perhaps unsurprising that the aforementioned conditions often have associated congenital genetic aberrations.

All the best,
Bill.

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Originally from: mark purdey
                        
Dear Bill,

I suppose you are aware of the interesting work that has been done by Stephen Whatley et al at the Institute of Psychiatry in London, where they identified some interaction between calcium ions at the calcium channels and prion protein function. I think Prusiner's team also published in this area.

This obviously strongly relates to what you are saying , and may also have some explanation for the high levels of barium / strontium that I have identified in the TSE clusters / hard tissues of TSE affected animals across North America. It is well known that Barium screws up these voltage gates, by substituting for calcium at these channels and inducing a hypokalemic rapid firing type reaction.

I have always felt that the copper attached to the prion protein has a role in conducting electrical signals – perhaps ?

Best,

Mark
                        

Originally from: Bill
                        
That sounds extremely interesting, Paul.

My opinion has been for a while that the healthy version of the so-called "prion" protein is a component in the mechanism for voltage controlled ion gates. Ion gates were at one time thought to be merely hypothetical "gates", but these incredible pieces of equipment really are gates that open and close extremely rapidly.

At some point in the not too distant future I hope to produce a graphic showing how the gates operate.

All the best,
Bill.
                        

Originally from: Bill
                        
Many thanks for that information, Mark.

The role of the copper atoms is interesting, though I don't think they are concerned with the conduction of electricity.

As far as I can work out the copper atoms act as hinge points which can either repel or attract other hinge points. Healthy alpha-helix molecules exist as pairs, not as a DNA type double helix but as two helix molecules in parallel.

A gate (which opens to form a pore) is comprised of four pairs of molecules, the pairs being arranged more or less radially. Each pair has one molecule towards the centre and one towards the outside and when in the closed position the molecules completely obscure the ion channel.

In order to open the pore each outer molecule appears to pull the inner molecule outwards, at the same time deflecting it (rather like a hand pulling a curtain open. Four hands pull four curtains open, resulting in exposure of a central pore. I hope that analogy portrays a reasonable picture, one day I really will get round to producing a graphic!

You can probably imagine though, changing the electric charge will cause the gate to open and close.

All the best,
Bill.
                        

Originally from: paul barton
                        
Hi Bill – the so called prion is in actual fact a Glycoprotein in most cases and its these carbohydrate molecules that are attached to the proteins that really interest me. We've seen disease states where sugar printing (developed by the President of the Royal Society of Medicine's John Axford to detect and predict Rheumatic conditions) has revealed structural abnormalities in glycosylation specific to the disease state. What we've also seen is that these glcyosylation defects can be addressed by the body given the right environment (nutrients). In discussion with my mother, who is actively participating in the Scrapie resistance programme (her sheep are), we wondered if the genetic i.e. Valine thread was being influenced by glycosylation defects?
Would like to talk on the phone at some stage if that would be possible. Regards Paul

From: ...

Originally from: ... [...] Sent: 05 October 2004 21:53
To: ...
Subject: Re: [farmtalking] Glycomics and genetics and scrapie

That sounds extremely interesting, Paul.

My opinion has been for a while that the healthy version of the so-called "prion" protein is a component in the mechanism for voltage controlled ion gates.
Ion gates were at one time thought to be merely hypothetical "gates", but these incredible pieces of equipment really are gates that open and close extremely rapidly.

At some point in the not too distant future I hope to produce a graphic showing how the gates operate.

All the best,
Bill.

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visit http://www.smartgroups.com/groups/farmtalking

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Originally from: paul barton
                        
Hi Mark
Has anyone made contact with Dr Reginald Mc Daniel – he is the real brains behind the application of glcyomics and various disease states in people and I suspect he has some valuable insights into the animal issues as well. He has been working on a hypothesis recently that suggests that the body, animal and human, can produce stem cells given the right conditions. His work number is 817–557–8700 ext 24 – he is the Medical director of a Charity called Manna Relief. ... he was invited to brief the US Congressional Committee on what could be done to support the immune system following a biological/chemical terrorist attack – which is just another environmental impact like the clusters you've been studying only more rapid and more widespread. Would appreciate the chance to talk on the phone? My number is 01752 769090
Regards paul barton